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Check Carefully (1)mitotane decreases amounts of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Mitotane is a strong inducer of cytochrome P-4503A4; keep track of when coadministered with CYP3A4 substrates for attainable dosage adjustments.Administration of benzodiazepines or other drugs that enhance GABAerg